Polycaprolactone CAS 24980-41-4

I. Malo Osindikizira a 3D: Zogwiritsidwa ntchito bwino kwambiri komanso zosinthika

Pankhani yosindikiza ya 3D (yopangira zowonjezera), polycaprolactone PCL yakhala imodzi mwa zipangizo zosindikizira za 3D zomwe zimatha kuwonongeka chifukwa cha malo ake otsika osungunuka (pafupifupi 60℃), kusungunuka bwino kwa madzi komanso mphamvu yolumikizirana pakati pa zigawo. Polima ya PCL ndi yoyenera kwambiri panjira zaukadaulo monga fused Deposition modeling (FDM) ndi stereolithography, ndipo imagwiritsidwa ntchito kwambiri pazochitika zotsatirazi:

Kupanga chitsanzo ndi chitsanzo chapadera:Polycaprolactone PCL ili ndi kutentha kocheperako komwe kumasokoneza kutentha, zomwe zimapangitsa kuti isapindike kapena kusweka panthawi yosindikiza. Imatha kubwereza bwino kapangidwe kake kovuta (monga zitsanzo zamakina ndi zitsanzo zazing'ono za zomangamanga), ndipo zigawo zosindikizidwa zimakhala zosalala kwambiri pamwamba, zomwe sizifuna kukonzedwa kwambiri pambuyo pake. Pakadali pano, mphamvu yowonongeka ya Polycaprolactone PCL imapangitsa kuti ikhale yoyenera kugwiritsidwa ntchito kamodzi kokha (monga zitsanzo zoyesera zida zamagalimoto), kuchepetsa kutayika kwa zinthu.

Kusindikiza kwa 3D kwa Biomedical Monga chinthu chokhala ndi mgwirizano wabwino kwambiri wa biomedical:Polycaprolactone PCL imadziwika bwino posindikiza ma scaffolds opangira minofu. Mwa kusintha kulemera kwa mamolekyu a chinthucho kapena kuchiphatikiza ndi zinthu zomwe zimagwira ntchito monga hydroxyapatite (HA) ndi collagen, ma scaffolds okhala ndi mapovu omwe amagwirizana ndi zomwe minofu ikufuna kukula monga mafupa ndi cartilage amatha kukonzedwa. Scaffolds imatha kuwonongeka pang'onopang'ono m'thupi, zomwe zimapangitsa kuti minofu yatsopano ikhale ndi malo othandizira. Pakadali pano, PCL polymer yagwiritsidwa ntchito pofufuza za zamankhwala monga kukonza mafupa ndi kukonzanso khungu.

M'magawo a maphunziro ndi luso:Kusungunuka kochepa kwa polycaprolactone PCL kumathandiza kusindikiza popanda kugwiritsa ntchito zida zotentha kwambiri, zomwe zimapangitsa kuti pakhale chitetezo champhamvu. Ndikoyenera ngati chida choyambirira chosindikizira cha 3D m'maphunziro. Polycaprolactone PCL imagwiritsidwa ntchito popanga zitsanzo zophunzitsira (monga zitsanzo za ziwalo za anthu ndi zitsanzo za kapangidwe ka molekyulu). Pakadali pano, khalidwe lake losasintha pang'onopang'ono kutentha kwa chipinda limathandizanso gawo la mapangidwe opanga popanga zomangira zaluso kapena zowonjezera zoseweretsa zokhala ndi mawonekedwe osinthika.

II. Malo Ogulitsira Chakudya Chotayika: Zitsimikizo ziwiri za kuwonongeka kwa zomera ndi chitetezo cha chitetezo

Pankhani yokonza chakudya chotayidwa, polycaprolactone PCL yakhala njira ina yofunika kwambiri m'malo mwa mapulasitiki achikhalidwe osawonongeka (monga polyethylene ndi polypropylene) chifukwa cha kuwonongeka kwake konse, zinthu zabwino zotchinga komanso chitetezo cha chakudya, zomwe zimathandiza kuthetsa vuto la "kuipitsidwa koyera". Mafomu ake akuluakulu ogwiritsira ntchito ndi awa:

Filimu/thumba losungira chakudya lowonongeka:PCL ikhoza kusakanizidwa ndi kusinthidwa ndi zinthu zachilengedwe monga starch ndi polylactic acid (PLA) kuti zinthuzo zizitha kusinthasintha komanso kukana madzi, ndipo ikhoza kupangidwa kukhala mafilimu kapena matumba osungiramo zinthu kuti zigwiritsidwe ntchito polongedza chakudya chatsopano (monga zipatso ndi ndiwo zamasamba) ndi chakudya chophikidwa - mtundu uwu wa phukusi ungagwiritsidwe ntchito m'malo achilengedwe (monga nthaka ndi zinthu zopangira manyowa) polycaprolactone PCL ikhoza kusokonekera pang'onopang'ono kukhala carbon dioxide ndi madzi mkati mwa miyezi 6 mpaka 12 popanda kusiya kuipitsidwa kulikonse. Pakadali pano, PCL polymer ili ndi kukhazikika kwabwino kwa mankhwala ndipo sichita ndi mafuta kapena zinthu zokhala ndi asidi muzakudya, zomwe zimakwaniritsa miyezo yachitetezo cha zinthu zokhudzana ndi chakudya (monga satifiketi ya FDA).

Zidebe ndi ziwiya zodyera zotayidwa:Kudzera mu jekeseni kapena njira zotenthetsera, polycaprolactone PCL imatha kuwonjezeredwa ndi ulusi wa zomera (monga ulusi wa udzu, ulusi wa nsungwi) kuti ipange mabokosi otayidwa a nkhomaliro, mbale, mipeni, mafoloko ndi zinthu zina. Mtundu uwu wa chinthu sumangokhala ndi mphamvu yabwino yonyamula katundu komanso kukana kutentha (kokhoza kupirira kutentha kwa chakudya chotentha cha 60-80℃), komanso polima wa PCL ukhozanso kuwonongeka kudzera mu kupanga manyowa mutagwiritsa ntchito, kupewa kuipitsa chilengedwe kwa nthawi yayitali komwe kumachitika chifukwa cha mbale zachikhalidwe zapulasitiki. Ndi yoyenera makamaka pazinthu zotayidwa zambiri monga kutenga chakudya chofulumira komanso kudya mwachangu.

III. Munda wa Zipangizo Zachipatala: Zipangizo zofunika kwambiri kuti zinthu zigwirizane ndi chilengedwe komanso kuti zigwirizane ndi ntchito

Pankhani ya mbale zachipatala, polycaprolactone (PCL) yakhala chinthu chofunikira kwambiri popanga mbale zokonzera zachipatala ndi mbale zoteteza chifukwa cha chitetezo chake chabwino cha zamoyo, kuchuluka kwa kuwonongeka komwe kungawongoleredwe komanso mphamvu zake zamakanika. Malangizo ake akuluakulu ogwiritsira ntchito ndi awa:

Mabolodi okonzera zachipatala:M'magawo monga opaleshoni ya mafupa ndi mano, polycaprolactone PCL imatha kukulitsa mphamvu zake zamakaniko kudzera mu kusintha (monga kuphatikiza hydroxyapatite ndi tricalcium phosphate), ndikupangidwa kukhala ma board okonzanso mafupa ndi ma alveolar bone reconstruction board. Pambuyo poyikidwa m'thupi la munthu, mtundu uwu wa bolodi sungangopereka chithandizo mwachangu kwa mafupa owonongeka komanso pang'onopang'ono kuwonongeka pamodzi ndi kukonzanso mafupa a thupi, kupewa chiopsezo cha opaleshoni yachiwiri kuti ichotsedwe. Pakadali pano, kuyanjana kwa polycaprolactone PCL kumatha kuchepetsa kukana kwa chitetezo chamthupi pambuyo poyikidwa, kulimbikitsa kulumikizidwa kwa maselo ndi kuphatikizana kwa minofu, ndipo kwagwiritsidwa ntchito kuchipatala mu opaleshoni yokonzanso mafupa yomwe siimayambitsa zovuta zambiri.

Mabodi oteteza ndi odzipatula azachipatala:PCL ili ndi mphamvu zabwino kwambiri zopangira filimu komanso zotchinga ndipo imatha kupangidwa kukhala ma board odzipatula azachipatala (monga ma board oteteza makoma a zipinda zochitira opaleshoni ndi zigawo zodzipatula pamwamba pa zida zachipatala). Mtundu uwu wa board sumangoletsa kulowa kwa mabakiteriya ndi mavairasi, komanso umasinthasintha komanso umalimbana ndi kupha tizilombo toyambitsa matenda. Umatha kupirira kupukuta mobwerezabwereza ndi mankhwala ophera tizilombo okhala ndi mowa ndi chlorine, ndipo umawonongeka ukatha kutayidwa, kuchepetsa kupsinjika kwa mankhwala otayira zinyalala zachipatala. Kuphatikiza apo, polycaprolactone PCL imathanso kuphatikizidwa ndi mankhwala ophera tizilombo (monga ma ion asiliva) kuti ipititse patsogolo magwiridwe antchito a antibacterial a board oteteza, zomwe zimapangitsa kuti ikhale yoyenera pazochitika zomwe zimafunikira kwambiri ukhondo wa chilengedwe, monga madipatimenti a matenda opatsirana ndi icus.

Iv. Magawo Ena: Magawo owonjezera ogwira ntchito

Kuwonjezera pa madera ofunikira omwe atchulidwa pamwambapa, polycaprolactone PCL imagwiranso ntchito pazochitika zosiyanasiyana:

Zophimba ndi zomatira:Polycaprolactone PCL, monga gawo lofunika kwambiri lopanga filimu la zokutira zochokera m'madzi kapena zosungunulira, imatha kukulitsa kusinthasintha, kukana kugwedezeka komanso kukana nyengo kwa zokutirazo - mwachitsanzo, ikagwiritsidwa ntchito pakhoma lakunja la mapaipi achitsulo, imatha kuchepetsa kusweka kwa zokutirazo komwe kumachitika chifukwa cha kupindika kwa mapaipi chifukwa cha kusintha kwa kutentha. Polycaprolactone PCL imagwiritsidwa ntchito ngati zokutira pamwamba pa zoseweretsa zapulasitiki, zomwe zimapangitsa kuti zokutirazo zikhale zolimba komanso zosachedwa kusweka. Komanso, popeza PCL yokha si poizoni, imatha kukwaniritsa miyezo yachitetezo cha zoseweretsa za ana. Kuphatikiza apo, kuwonjezera polima wa PCL pazophimba zamatabwa kungathandizenso kukongoletsa utoto wa tirigu wamatabwa ndikuwonjezera mawonekedwe ake.

Zipangizo zaulimi:Polycaprolactone PCL imapangidwa kukhala mafilimu a zaulimi owonongeka, omwe amagwiritsidwa ntchito pobzala mbande, kusunga madzi ndi feteleza. Pambuyo powonongeka, amatha kusinthidwa kukhala zinthu zachilengedwe m'nthaka, kupewa kuipitsidwa kwa nthaka komwe kumachitika chifukwa cha mafilimu otsala. Kapena ikhoza kupangidwa kukhala chonyamulira feteleza chotulutsa pang'onopang'ono kuti chiwongolere kuchuluka kwa michere yomwe imatulutsidwa, ndipo PCL polymer imatha kusintha kuchuluka kwa feteleza komwe imagwiritsidwira ntchito. Mbali ya "kuwonongeka kolamulirika" ya PCL imakwaniritsa bwino zofunikira zaulimi za "ntchito" ndi "kusamalira chilengedwe", ndipo imagwiritsidwa ntchito makamaka kuthetsa mavuto a kuipitsidwa kwa zipangizo zaulimi zachikhalidwe.

Chosinthira zinthu zophatikizika:Polycaprolactone PCL imasakanizidwa ndi polyolefins, polyester ndi zipangizo zina kuti ziwongolere kusinthasintha kwawo ndi mphamvu zawo, zomwe zimapangitsa kuti ikhale yoyenera pazochitika zomwe zimafunikira kwambiri kuti zinthu zigwire ntchito bwino, monga zida zamkati zamagalimoto ndi zipolopolo za zida zapakhomo.

Kusintha kwa ulusi/nsalu:Polycaprolactone PCL imagwiritsidwa ntchito popaka kapena kuyika ulusi wa polyester ndi thonje kuti iwonjezere kusinthasintha, kukana kukalamba komanso mphamvu zotsutsana ndi makwinya. Mwachitsanzo, kuwonjezera chophimba cha PCL ku nsalu zamasewera kungapangitse kuti nsaluzo zikhale zosavuta kutambasuka komanso kuti zisawonongeke. Kuyika PCL mu ulusi wa gauze wachipatala kungathandize kuyamwa chinyezi ndi kusunga gauze, kukonza kumamatira kwake pakhungu, ndikuchepetsa kusasangalala komwe kumachitika chifukwa cha kukangana kwa mabala.