nkhani

Hydroxypropyl beta-cyclodextrin, yomwe imadziwikanso kuti (2-hydroxypropyl) -β-cyclodextrin, ndi atomu ya haidrojeni m'magulu a 2-, 3-, ndi 6-hydroxyl a zotsalira za glucose mu β-cyclodextrin (β-CD) yomwe imasinthidwa ndi hydroxypropyl kuti hydroxypropoxy. HP-β-CD sikuti imakhala ndi envulopu yabwino kwambiri pamagulu ambiri monga β-CD, komanso ili ndi ubwino wa kusungunuka kwamadzi kwambiri komanso kupititsa patsogolo kuchuluka kwa kutulutsidwa ndi bioavailability wa mankhwala otsekedwa mu vivo. Kuonjezera apo, HP-β-CD ndi wothandizira mankhwala omwe ali ndi deta yochuluka kwambiri ya chitetezo yomwe imasonkhanitsidwa ndipo palibe zotsatirapo zoipa. HP-β-CD itha kugwiritsidwanso ntchito ngati choteteza mapuloteni ndi stabilizer.

Hydroxypropyl beta-cyclodextrin ndi woyera kapena woyera amorphous kapena crystalline ufa; Zopanda fungo, zotsekemera pang'ono; Kulowetsedwa kwamphamvu kwa chinyezi. Izi zimasungunuka mosavuta m'madzi, zimasungunuka mosavuta mu methanol, ethanol, pafupifupi insoluble mu acetone, trichloromethane.

The solubility wahydroxypropyl -B-cyclodextrinm'madzi ndi zabwino kwambiri, ndipo m'malo digiri 4 ndi pamwamba akhoza miscible madzi mu gawo lililonse, ndipo akhoza kusungunuka mu 50% Mowa ndi methanol. Ili ndi hygroscopicity yofananira. Koma zochita zapamtunda ndi ntchito za hemolytic ndizochepa. Ilibe kukwiya kwa minofu ndipo ndi yabwino zosungunulira zowonjezera ndi mankhwala excipient jekeseni.

Kodi Hydroxypropyl beta-cyclodextrin amagwiritsidwa ntchito chiyani?

M'munda wa zakudya ndi zonunkhira

Hydroxypropyl beta-cyclodextrin imatha kupititsa patsogolo kukhazikika komanso kugwira ntchito kwanthawi yayitali kwa mamolekyu azakudya, kubisa kapena kukonza fungo loyipa komanso kukoma kwa mamolekyu azakudya, ndikuwongolera njira yopangira komanso mtundu wazinthu.

Mu zodzoladzola

Zopangira zodzoladzola zitha kugwiritsidwa ntchito ngati stabilizers, emulsifiers, deodorizers, etc., zomwe zingachepetse kukondoweza kwa mamolekyu achilengedwe mu zodzoladzola pakhungu ndi mucous nembanemba, kumapangitsa kukhazikika kwa zosakaniza zogwira ntchito, ndikuletsa kusinthika ndi makutidwe ndi okosijeni a zakudya. . Ili ndi hygroscopicity yachibale.

M'munda wamankhwala

Hydroxypropyl beta-cyclodextrinamatha kusungunuka m'madzi a mankhwala osasungunuka, kuonjezera kukhazikika kwa mankhwala, kusintha bioavailability ya mankhwala, kuonjezera mphamvu ya kukonzekera kwa mankhwala kapena kuchepetsa mlingo, kusintha kapena kuwongolera kuthamanga kwa mankhwala, ndi kuchepetsa kawopsedwe ka mankhwala. Itha kugwiritsidwa ntchito ngati chonyamulira cha mankhwala pakamwa, jakisoni, mucosal mankhwala yobereka kachitidwe (kuphatikizapo mphuno mucosa, rectum, cornea, etc.), transdermal mayamwidwe mankhwala yobereka kachitidwe, lipophilic chandamale mankhwala, komanso angagwiritsidwe ntchito ngati chitetezo mapuloteni ndi stabilizer.