nkhani

Hydroxypropyl beta-cyclodextrin, yomwe imadziwikanso kuti (2-hydroxypropyl) -β-cyclodextrin, ndi atomu ya haidrojeni yomwe ili m'magulu a 2-, 3-, ndi 6-hydroxyl a zotsalira za shuga mu β-cyclodextrin (β-CD) yomwe imasinthidwa ndi hydroxypropyl kukhala hydroxypropoxy. HP-β-CD sikuti imangokhala ndi zotsatira zabwino kwambiri pa mankhwala ambiri monga β-CD, komanso ili ndi ubwino wosungunuka kwambiri m'madzi ndikukweza kuchuluka kwa kutulutsidwa ndi kupezeka kwa mankhwala omwe ali mkati mwa thupi. Kuphatikiza apo, HP-β-CD ndi mankhwala othandizira omwe ali ndi deta yotetezeka kwambiri yosonkhanitsidwa ndipo palibe zotsatira zoyipa. HP-β-CD ingagwiritsidwenso ntchito ngati choteteza mapuloteni komanso chokhazikika.

Hydroxypropyl beta-cyclodextrin ndi ufa woyera kapena woyera wosapanga mawonekedwe kapena wonyezimira; Wopanda fungo, wotsekemera pang'ono; Wopatsa chinyezi champhamvu. Chogulitsachi chimasungunuka mosavuta m'madzi, chimasungunuka mosavuta mu methanol, ethanol, sichisungunuka kwambiri mu acetone, trichloromethane.

Kusungunuka kwahydroxypropyl-B-cyclodextrinMu madzi ndi wabwino kwambiri, ndipo mlingo wosinthira wa 4 ndi kupitirira apo ukhoza kusakanikirana ndi madzi molingana ndi momwe zinthu zilili, ndipo ukhozanso kusungunuka mu 50% ethanol ndi methanol. Ili ndi hygroscopicity inayake. Koma ntchito yoyerekeza pamwamba ndi ntchito ya hemolytic ndi yochepa. Siili ndi kuyabwa kwa minofu ndipo ndi chinthu chabwino kwambiri chowonjezera zosungunulira komanso chothandizira mankhwala pobayira.

Kodi Hydroxypropyl beta-cyclodextrin imagwiritsidwa ntchito chiyani?

Mu gawo la chakudya ndi zonunkhira

Hydroxypropyl beta-cyclodextrin imatha kukonza kukhazikika ndi magwiridwe antchito a nthawi yayitali a mamolekyulu azakudya, kuphimba kapena kukonza fungo loipa ndi kukoma kwa mamolekyulu azakudya, ndikukweza njira yopangira ndi mtundu wa zinthu.

Mu zodzoladzola

Zipangizo zopangira zodzoladzola zitha kugwiritsidwa ntchito ngati zokhazikika, zosakaniza, zochotsera fungo loipa, ndi zina zotero, zomwe zingachepetse kukondoweza kwa mamolekyu achilengedwe mu zodzoladzola pakhungu ndi minofu ya mucous membrane, kulimbitsa kukhazikika kwa zosakaniza zogwira ntchito, ndikuletsa kusinthasintha ndi kukhuthala kwa michere. Ili ndi hygroscopicity inayake.

Mu gawo la zamankhwala

Hydroxypropyl beta-cyclodextrinIkhoza kupititsa patsogolo kusungunuka kwa mankhwala osasungunuka m'madzi, kuwonjezera kukhazikika kwa mankhwala, kuwonjezera kupezeka kwa mankhwala, kuwonjezera mphamvu ya mankhwala okonzekera kapena kuchepetsa mlingo, kusintha kapena kuwongolera liwiro la kutulutsa mankhwala, ndikuchepetsa poizoni wa mankhwala. Itha kugwiritsidwa ntchito ngati chonyamulira mankhwala omwa, jakisoni, njira zoperekera mankhwala mu mucosal (kuphatikiza mucosa ya m'mphuno, rectum, cornea, ndi zina zotero), njira zoperekera mankhwala olowetsedwa m'mphuno, mankhwala oledzera lipophilic, ndipo ingagwiritsidwenso ntchito ngati choteteza mapuloteni komanso chokhazikika.