2,5-Dimethoxybenzaldehyde CAS 93-02-7

Kuphatikiza pa kukhala oxidized kapena kuchepetsedwa kukhala 2,5-dimethoxybenzoic acid, benzonitrile kapena benzyl mowa, 2,5-dimethoxybenzaldehyde palokha ilinso ndi phindu lapadera la ntchito. Pochita zinthu ndi mitundu yosiyanasiyana yamagulu ogwira ntchito, mamolekyu a mankhwala omwe ali ndi mapangidwe osiyanasiyana ndi zotsatira zosiyana angapezeke. Matenda a Parkinson (PD) ndi matenda omwe amapezeka mu neurodegenerative, ndipo zizindikiro zake zazikulu zamatenda zimaphatikizapo kunjenjemera kwa minofu, kusasunthika, kusayenda bwino, kaimidwe ka thupi komanso kusayenda bwino. Kupititsa patsogolo kumapangitsanso kuzindikira, kuzindikira, kusokonezeka kwa kukumbukira ndi kusokonezeka maganizo. Pakalipano, chithandizo cha PD makamaka chimaphatikizapo mankhwala osokoneza bongo, chithandizo cha opaleshoni ndi chithandizo cha majini. Pochiza mankhwala, phenamidine inapezeka kuti ili ndi zotsatira zabwino pa PD, yokhala ndi poizoni wochepa komanso chitetezo chabwino, ndipo kaphatikizidwe ka phenamidine kumafuna kugwiritsa ntchito 2,5-dimethoxybenzaldehyde monga chiyambi.

Malinga ndi kaphatikizidwe kachitidwe kofotokozedwa m'mabuku, 2,5-dimethoxybenzaldehyde imapezeka makamaka pochita 1,4-dimethoxybenzene ndi formylation agent. Formylation agents akuphatikizapo (1) osakaniza a 1,1-dichloromethyl ether ndi titaniyamu tetrachloride; (2) chisakanizo cha N,N-dimethylformamide ndi phosphorous oxychloride, chisakanizo cha N,N-dimethylformamide ndi oxalyl chloride; (3) chisakanizo cha N,N-dimethylformamide ndi thionyl chloride kapena chisakanizo cha urotropine ndi magnesium chloride. Komabe, njirazi zimafuna kugwiritsa ntchito titaniyamu tetrachloride yambiri, phosphorous oxychloride kapena thionyl chloride. Ma reagents awa ndi osakhazikika komanso amawola mosavuta, ndipo mpweya wambiri wa hydrochloric acid umatulutsidwa panthawi ya zomwe zimachitika, zomwe sizigwirizana ndi chilengedwe komanso zimakhala ndi zofunika kwambiri pakuchita opaleshoni.

Njira yatsopano yophatikizira yaperekedwa. Njirayi imagwiritsa ntchito 1,4-dimethoxybenzene ndi formaldehyde monga zopangira, ndipo imapanga photooxidative coupling reaction pamaso pa mpweya ndi chothandizira pansi pa kuwala kwa buluu kuti apange bwino 2,5-dimethoxybenzaldehyde. Njira imeneyi imagwiritsa ntchito mpweya kapena mpweya monga okosijeni, sipanga mpweya wa acidic, komanso ndi yogwirizana ndi chilengedwe. Kuonjezera apo, njirayi imagwiritsa ntchito cobalt yotsika mtengo monga chothandizira, chomwe chiri chotsika mtengo komanso choyenera kugwiritsira ntchito mafakitale.